Many of our providers are principal investigators (PI's) engaged in laboratory research. The following are links to more information about their programs.
The Baranzini Lab
Our lab is interested in the genetics and molecular mechanisms underlying complex diseases. In particular, we use a combination of wet and dry lab approaches to investigate the disease multiple sclerosis, an autoimmune disorder of the central nervous system. Work in our lab involves human genetics, immunology, molecular biology, bioinformatics and systems biology approaches. Please visit our lab website by clicking here.
The Bove Lab
We are committed to finding new ways of improving the lives of people living with multiple sclerosis (MS), including through new technologies and hormonal modulation. Please visit our lab website by clicking here.
The Chan Lab
Jonah Chan, PhD is principal investigator whose lab is working to understand the fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Please visit our lab website by clicking here.
The Green Lab
The Green Lab focuses on advanced measures of the visual system to help further the care of neurological disease. Please visit our lab website by clicking here.
Molecular Neuroimmunology and Neurogenetics
The principal aim of our laboratory is to identify the major genetic factors that predispose to autoimmunity and tissue injury in the central nervous system. Our goals are to apply and integrate novel molecular, immunological, informatic, statistical, and epidemiological experimental approaches, and translate this information into better diagnosis, prognosis, treatment and prevention of multiple sclerosis and other neuroinflammatory diseases. Please visit our lab website by clicking here.
Neurogenesis and Oligodentritics Biology
Sam Pleasure, MD, PhD is principal investigator whose lab is studying patterning, morphogenesis, migration and connectivity in the developing brain using genetic and in vitro manipulation. Please visit our lab website by clicking here.
The Wilson/B cell Neuroimmunology Lab
We study how B cells are involved in central nervous system (CNS) inflammatory and neuro-infectious disorders ranging from multiple sclerosis (MS), the most common chronic neurological disease of young adults, to more unusual conditions like meningitis and encephalitis. Using human samples (e.g., serum, cerebrospinal fluid and brain tissue) collected at disease onset, we identify infectious agents, novel antibodies and characterize B and T cell responses with the aim of better understanding infectious and/or autoimmune mechanisms of disease. Our goal is to use newly gained knowledge for translation into therapies and disease markers. Please visit our lab website by clicking here.
The Zamvil Lab
The focus of our research is to investigate the mechanisms involved in the regulation of antigen presentation and T cell activation in the central nervous system (CNS) autoimmune disease model, experimental autoimmune encephalomyelitis (EAE). Our goal is to apply this knowledge to the development of new treatments for multiple sclerosis (MS). Molecular, cellular, and both in vivo transgenic and knock-out approaches are utilized in our work. Please visit our lab website by clicking here.